Treatment overview
In contemporary aesthetic dermatology, we are increasingly moving away from surface-level solutions and focusing on skin regeneration at the cellular level. This is precisely where polynucleotides come in — one of the most advanced therapies for renewing the skin from within.
Mastelli polynucleotides are highly purified biological molecules that act as potent biostimulators, encouraging the skin’s natural processes of regeneration, renewal, and protection.
Their effect is based on:
- stimulation of fibroblasts (the cells responsible for collagen)
- improvement of hydration and elasticity
- regeneration of damaged tissue
- reduction of inflammatory processes
Unlike treatments that deliver an immediate effect of volume or tightening, polynucleotides work more deeply and with longer-lasting results — improving skin quality from within, making it more resilient, healthier, and more vital.
Notably, polynucleotides have been used in medicine for many years for tissue regeneration (for example, in ophthalmology and dermatology), and have today become one of the most sought-after biostimulation treatments in premium aesthetic medicine.
Patients often present with the feeling that their skin looks “worn”, thinner, or lacking elasticity — even in the absence of pronounced lines.
This is that subtle yet significant moment when the skin loses its quality, and the face no longer reflects freshness and vitality.
In everyday and professional settings, it is precisely this skin quality that conveys a sense of grooming, health, and confidence — without the need for any “visible” treatment.
Polynucleotides do not change the face — they restore the skin’s natural strength and capacity for renewal.
How is the treatment performed?
The treatment is carried out via microinjections into targeted areas of the skin.
During the procedure:
- the condition of the skin is assessed
- treatment zones are defined
- the preparation is applied to the superficial and mid layers of the skin
The procedure is minimally invasive and precise.
Who is the treatment for?
The treatment is ideal for individuals who:
- wish to improve skin quality and texture
- notice a loss of elasticity and tone
- have thin or sensitive skin
- seek a natural anti-ageing approach without added volume
It is also suitable for those seeking regeneration following other treatments.
Our approach
Polynucleotides are not a “trend treatment” — they are a therapy that requires proper clinical indication.
At our clinic, treatment is planned individually, according to the patient’s skin condition and goals.
We do not apply it routinely — only when it can truly deliver maximum benefit.
We frequently integrate it into a broader regeneration plan, alongside other biostimulative methods.
We take time for thorough assessment and explanation — because we want you to fully understand the process and what to expect.
Patients most commonly notice a gradual improvement — the skin appears denser, higher in quality, and healthier.
Preparing for the treatment
Prior to the treatment, we recommend:
- arriving with clean skin
- avoiding aggressive treatments for a few days beforehand
- informing your doctor of any current medications or therapies
An anaesthetic cream may be applied if required.
Recovery and precautions
Recovery is minimal.
Following the treatment:
- mild redness is possible
- small papules at the injection sites may appear
Recommendations:
- avoid sun exposure and use SPF
- do not apply aggressive skincare products
When are results visible?
Results develop gradually.
- initial effects within a few weeks
- full results over several months
Results include:
- improved elasticity
- better skin texture
- a healthy and natural appearance
Treatment combinations
For maximum regenerative effect:
- Morpheus8 — for collagen stimulation
- CO2 Smaxel — for skin regeneration
- Candela Nordlys — for skin tone quality
- HIFU — for lifting
- Icoone Laser Med — for microcirculation
Additionally:
- PRP treatments
- exosomes
All combinations are planned individually — for optimal results.
